Cream Presentation

Each tube contains:
Mometasone Furoate 1 mg

Mometasone furoate cream is a prescription medicine used on the skin (topical) for the relief of redness, swelling, heat, pain (inflammation) and itching, caused by certain skin problems in people 2 years of age and older.

Indication

• Skin Inflammation
• Acne Vulgaris
• Pruritus
• Dermatitis

Mechanism of action

Mometasone is a synthetic corticosteroid with an affinity for glucocorticoid receptors 22 times higher than that of dexamethasone. Mometasone furoate also has a lower affinity to mineralocorticoid receptors than natural corticosteroids, making it more selective in its action2. Mometasone furoate diffuses across cell membranes to activate pathways responsible for reducing inflammation.

Mometasone furoate binding to a glucocorticoid receptor causes conformational changes in the receptor, separation from chaperones, and the receptor moves to the nucleus. Once at the nucleus, receptors dimerize and bind to a DNA sequence known as the glucocorticoid response element which either increases expression of anti-inflammatory molecules or inhibits expression of pro-inflammatory molecules (such as interleukins 4 and 5). Mometasone furoate also reduces inflammation by blocking transcription factors such as activator-protein-1 and nuclear factor kappa B (NF-kappaB).

Side Effects

The cream is considered as safe when used in recommended doses however severe or mild skin irritation, red or pus-filled bumps on your skin, acne, tingling or burning sensation can occur in some patients.

Interactions

It can react with other steroids, vitamins, and herbal products.

Contraindications

• Not to be used in children below 2 years.
• Not to be used in pregnancy and breast feeding.

Precaution

• Wash your hands after use.
• Avoid contact with your eyes, nose, mouth or any areas of broken skin.